[Imaging of pediatric brain tumors using somatostatin analogue 111Ih-DTPA-D-Phe1-octreotide].
Identifieur interne : 002491 ( Main/Exploration ); précédent : 002490; suivant : 002492[Imaging of pediatric brain tumors using somatostatin analogue 111Ih-DTPA-D-Phe1-octreotide].
Auteurs : RBID : pubmed:17922063English descriptors
- KwdEn :
- Adolescent, Astrocytoma (radionuclide imaging), Brain Neoplasms (radionuclide imaging), Child, Child, Preschool, Ependymoma (radionuclide imaging), Female, Glioblastoma (radionuclide imaging), Humans, Indium Radioisotopes (diagnostic use), Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Medulloblastoma (radionuclide imaging), Octreotide (analogs & derivatives), Octreotide (diagnostic use), Pentetic Acid (analogs & derivatives), Pentetic Acid (diagnostic use), Radiopharmaceuticals (diagnostic use), Receptors, Somatostatin (metabolism).
- MESH :
- chemical , analogs & derivatives : Octreotide, Pentetic Acid.
- chemical , diagnostic use : Indium Radioisotopes, Octreotide, Pentetic Acid, Radiopharmaceuticals.
- chemical , metabolism : Receptors, Somatostatin.
- radionuclide imaging : Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma.
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male.
Abstract
Malignant solid tumors and leukemias are the second most common causes of death in childhood. The most frequent pediatric solid tumors are brain tumors. Brain tumors, especially medulloblastoma should be treated by surgery, irradiation and chemotherapy. However, chemotherapy has only moderate effect. Pediatric brain tumors, especially medulloblastomas, express somatostatin receptors. The aim of this study was the investigation of the expression of somatostatin receptors in pediatric brain tumors for diagnostic and therapeutic purpose. Fifty-six scintigraphic imagings (111In-DTPA-D-Phe1-octreotide) made in 45 children treated with brain tumor at the Unit of Oncology of the 2nd Department of Pediatrics, Semmelweis University. The diagnosis was medulloblastoma in 21 cases (46.7%). MRI scans have been performed parallel with the Octreoscan images. Octreoscan images were positive in 27 of 56 (48.2%) cases. The 27 positive Octreoscan images consisted of 16 medulloblastomas, 4 ependymomas, 4 astrocytomas and 3 glioblastomas. In 37 (66.1%) cases the results of Octreoscans were the same as those of the MRI scans. However, in 19 scans (33.9%) the outcome was different. Octreoscan imaging is not suitable for differential diagnosis in pediatric brain tumors, including medulloblastomas. Isotopes specifically binding to the somatostatin receptors (111In-DTPA-D-Phe1-octreotide) can be applied in medulloblastomas for diagnosis and follow-up treatment. In Octreoscan-positive tumors the Octreoscan images establish the opportunity to somatostatin analogue and/or specifically targeted radiation therapies.
DOI: HUON.2007.51.3.0229
PubMed: 17922063
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Imaging of pediatric brain tumors using somatostatin analogue 111Ih-DTPA-D-Phe1-octreotide].</title><author><name sortKey="Dabasi, Gabriella" uniqKey="Dabasi G">Gabriella Dabasi</name><affiliation wicri:level="1"><nlm:affiliation>Transzplantációs és Sebészeti Klinika, Semmelweis Egyetem AOK, Budapest, Hungary. dabasi@trans.sote.hu</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Transzplantációs és Sebészeti Klinika, Semmelweis Egyetem AOK, Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Peter" uniqKey="Hauser P">Péter Hauser</name></author><author><name sortKey="Kertesz, Gabriella P" uniqKey="Kertesz G">Gabriella P Kertész</name></author><author><name sortKey="Bal Zs, Gy Rgy" uniqKey="Bal Zs G">György Balázs</name></author><author><name sortKey="Kar Di, Zolt N" uniqKey="Kar Di Z">Zoltán Karádi</name></author><author><name sortKey="Constantin, Tam S" uniqKey="Constantin T">Tamás Constantin</name></author><author><name sortKey="Bogn R, L Szl" uniqKey="Bogn R L">László Bognár</name></author><author><name sortKey="Klekner, Almos" uniqKey="Klekner A">Almos Klekner</name></author><author><name sortKey="Schuler, Dezso" uniqKey="Schuler D">Dezsô Schuler</name></author><author><name sortKey="Garami, Mikl S" uniqKey="Garami M">Miklós Garami</name></author></titleStmt><publicationStmt><date when="2007">2007</date><idno type="doi">HUON.2007.51.3.0229</idno><idno type="RBID">pubmed:17922063</idno><idno type="pmid">17922063</idno><idno type="wicri:Area/Main/Corpus">002634</idno><idno type="wicri:Area/Main/Curation">002634</idno><idno type="wicri:Area/Main/Exploration">002491</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Astrocytoma (radionuclide imaging)</term><term>Brain Neoplasms (radionuclide imaging)</term><term>Child</term><term>Child, Preschool</term><term>Ependymoma (radionuclide imaging)</term><term>Female</term><term>Glioblastoma (radionuclide imaging)</term><term>Humans</term><term>Indium Radioisotopes (diagnostic use)</term><term>Infant</term><term>Infant, Newborn</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Medulloblastoma (radionuclide imaging)</term><term>Octreotide (analogs & derivatives)</term><term>Octreotide (diagnostic use)</term><term>Pentetic Acid (analogs & derivatives)</term><term>Pentetic Acid (diagnostic use)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Receptors, Somatostatin (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Octreotide</term><term>Pentetic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Octreotide</term><term>Pentetic Acid</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Somatostatin</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Astrocytoma</term><term>Brain Neoplasms</term><term>Ependymoma</term><term>Glioblastoma</term><term>Medulloblastoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Malignant solid tumors and leukemias are the second most common causes of death in childhood. The most frequent pediatric solid tumors are brain tumors. Brain tumors, especially medulloblastoma should be treated by surgery, irradiation and chemotherapy. However, chemotherapy has only moderate effect. Pediatric brain tumors, especially medulloblastomas, express somatostatin receptors. The aim of this study was the investigation of the expression of somatostatin receptors in pediatric brain tumors for diagnostic and therapeutic purpose. Fifty-six scintigraphic imagings (111In-DTPA-D-Phe1-octreotide) made in 45 children treated with brain tumor at the Unit of Oncology of the 2nd Department of Pediatrics, Semmelweis University. The diagnosis was medulloblastoma in 21 cases (46.7%). MRI scans have been performed parallel with the Octreoscan images. Octreoscan images were positive in 27 of 56 (48.2%) cases. The 27 positive Octreoscan images consisted of 16 medulloblastomas, 4 ependymomas, 4 astrocytomas and 3 glioblastomas. In 37 (66.1%) cases the results of Octreoscans were the same as those of the MRI scans. However, in 19 scans (33.9%) the outcome was different. Octreoscan imaging is not suitable for differential diagnosis in pediatric brain tumors, including medulloblastomas. Isotopes specifically binding to the somatostatin receptors (111In-DTPA-D-Phe1-octreotide) can be applied in medulloblastomas for diagnosis and follow-up treatment. In Octreoscan-positive tumors the Octreoscan images establish the opportunity to somatostatin analogue and/or specifically targeted radiation therapies.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17922063</PMID><DateCreated><Year>2007</Year><Month>10</Month><Day>08</Day></DateCreated><DateCompleted><Year>2008</Year><Month>03</Month><Day>17</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0025-0244</ISSN><JournalIssue CitedMedium="Print"><Volume>51</Volume><Issue>3</Issue><PubDate><Year>2007</Year></PubDate></JournalIssue><Title>Magyar onkologia</Title><ISOAbbreviation>Magy Onkol</ISOAbbreviation></Journal><ArticleTitle>[Imaging of pediatric brain tumors using somatostatin analogue 111Ih-DTPA-D-Phe1-octreotide].</ArticleTitle><Pagination><MedlinePgn>229-34</MedlinePgn></Pagination><Abstract><AbstractText>Malignant solid tumors and leukemias are the second most common causes of death in childhood. The most frequent pediatric solid tumors are brain tumors. Brain tumors, especially medulloblastoma should be treated by surgery, irradiation and chemotherapy. However, chemotherapy has only moderate effect. Pediatric brain tumors, especially medulloblastomas, express somatostatin receptors. The aim of this study was the investigation of the expression of somatostatin receptors in pediatric brain tumors for diagnostic and therapeutic purpose. Fifty-six scintigraphic imagings (111In-DTPA-D-Phe1-octreotide) made in 45 children treated with brain tumor at the Unit of Oncology of the 2nd Department of Pediatrics, Semmelweis University. The diagnosis was medulloblastoma in 21 cases (46.7%). MRI scans have been performed parallel with the Octreoscan images. Octreoscan images were positive in 27 of 56 (48.2%) cases. The 27 positive Octreoscan images consisted of 16 medulloblastomas, 4 ependymomas, 4 astrocytomas and 3 glioblastomas. In 37 (66.1%) cases the results of Octreoscans were the same as those of the MRI scans. However, in 19 scans (33.9%) the outcome was different. Octreoscan imaging is not suitable for differential diagnosis in pediatric brain tumors, including medulloblastomas. Isotopes specifically binding to the somatostatin receptors (111In-DTPA-D-Phe1-octreotide) can be applied in medulloblastomas for diagnosis and follow-up treatment. In Octreoscan-positive tumors the Octreoscan images establish the opportunity to somatostatin analogue and/or specifically targeted radiation therapies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dabasi</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials><Affiliation>Transzplantációs és Sebészeti Klinika, Semmelweis Egyetem AOK, Budapest, Hungary. dabasi@trans.sote.hu</Affiliation></Author><Author ValidYN="Y"><LastName>Hauser</LastName><ForeName>Péter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Kertész</LastName><ForeName>Gabriella P</ForeName><Initials>GP</Initials></Author><Author ValidYN="Y"><LastName>Balázs</LastName><ForeName>György</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Karádi</LastName><ForeName>Zoltán</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Constantin</LastName><ForeName>Tamás</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Bognár</LastName><ForeName>László</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Klekner</LastName><ForeName>Almos</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Schuler</LastName><ForeName>Dezsô</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Garami</LastName><ForeName>Miklós</ForeName><Initials>M</Initials></Author></AuthorList><Language>hun</Language><PublicationTypeList><PublicationType>English Abstract</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Gyermekkori agytumorok vizsgálata szomatosztatin-analóg (111In-DTPA-D-Phe1-octreotide) alkalmazásával.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2007</Year><Month>10</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Hungary</Country><MedlineTA>Magy Onkol</MedlineTA><NlmUniqueID>9313833</NlmUniqueID><ISSNLinking>0025-0244</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Receptors, Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>142694-57-3</RegistryNumber><NameOfSubstance>SDZ 215-811</NameOfSubstance></Chemical><Chemical><RegistryNumber>7A314HQM0I</RegistryNumber><NameOfSubstance>Pentetic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>RWM8CCW8GP</RegistryNumber><NameOfSubstance>Octreotide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Astrocytoma</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Brain Neoplasms</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Ependymoma</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Glioblastoma</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Medulloblastoma</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Octreotide</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pentetic Acid</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Receptors, Somatostatin</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2006</Year><Month>12</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>8</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2007</Year><Month>10</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>10</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>3</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>10</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">HUON.2007.51.3.0229</ArticleId><ArticleId IdType="pubmed">17922063</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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